These are the ones that have an image that updates itself, or a video playing. I'm not sure just what this would be on your machine, it may depend on what you have in 'startup', but also I would be looking at things like 'live tiles' on the start menu. If you are not using Edge yourself then something else must be starting it in the background. The real solution would be to find out what is causing Edge to be open all the time and stop it from doing so. That way you won't get the popup asking you to close Edge everytime you run CC.
If you untick all Edge items then CC will not analyse or clean them, then you could right click each unticked item and do a manual clean once in a while. It's more of an issue of why Edge is running all the time.
I wouldn't call it an 'issue' with CC, CC is just doing it's job as it's supposed to.
